LY294002 treatment

Species: Fruit fly (Taxid: 7227)
Factor: LY294002
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment of Drosophila imago with 5 micromolar LY294002 increases median (by 14%) and maximum (by 16-22%) lifespan (p<0.001) in females and males, respectively [22661237].

Low dose of LY294002 (5 microM) slightly increase the median and maximum lifespan [20017609].

Median: +14
Maximum: +16 to +22

References:
  • 22661237: The second international conference "genetics of aging and longevity".
  • 20017609: Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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