Denigma

faah-1 overexpression

Species: Nematode (Taxid: 6239)
Factor: faah-1
Manipulation: Gain-of-Function, Overexpression
Effect:

faah-1 overexpression reduces eicosapentaenoyl ethanolamide (EPEA), palmitoleyol ethanolamide, linoleyol ethanolamide, as well as arachidonoyl ethanolamide (AEA) levels, delays development, increases thermal stress resistance, and was associated with mean and maximum adult lifespan extension by 19 and 35%, respectively, in presence of abundant food but not under (two different protocols of) DR. Overexpression in pharynx was largely sufficient for this lifespan extension [21562563].

Mean: +19
Maximum: +35

References:
  • 21562563: N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit