Denigma

Bmcp knockout

Species: Fruit fly (Taxid: 7227)
Factor: Bmcp
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Bmcp knockout flies live longer on low-calorie diets, have a decreased fertility, and gain less weight on high-calorie diets. Bmcp (ucp5) knockout mutants live longer than wild-type on low-calorie diets, but no longer on starvation or high-calorie diets. Ectopic neuronal expression of Bmcp transgene rescues starvation sensitive phenotype of Bmcp knockout mutants [16387864].


References:
  • 16387864: Involvement of Drosophila uncoupling protein 5 in metabolism and aging.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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