Denigma

Heterzygous Rpd3 null mutation

Species: Fruit fly (Taxid: 7227)
Factor: Rpd3
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Males heterozygous for a null mutation of Rpd3 have a lifespan extension of 41 - 47%. Females carrying a null mutation have only modest increase in maximum lifespan (but not median lifespan). Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet. DR fails to further increase lifespan of rpd3 mutants [12459580].

Mean: +41 to +47

References:
  • 12459580: Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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