Denigma

Heterozygous hypomorphic Rpd3 mutation

Species: Fruit fly (Taxid: 7227)
Factor: Rpd3
Manipulation: Loss-of-Function, Knockdown, Mutation
Effect:

Males heterozygous for hypomorphic (partial loss-of-function) mutation of Rpd3 have a lifespan extension of 33%. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan. Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet [12459580].

Mean: +33 to 52

References:
  • 12459580: Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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