Denigma: Intervention

Homozygous chico mutation

Species: Fruit fly (Taxid: 7227)
Factor: chico
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation in chico extends mean, median, and maximum lifespan by 56%, 48%, and 42% in homozygotes. chico mutation produces dwarf, long-lived females at normal nutrition [11292874]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [11951037]. Male chico homozygous have a shortened lifespan [11292874]. Female chico homozygous recessive mutants are sterile [11292874].

Mean: +56
Median: +48
Maximum: +42

References:

11292874: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

11951037: Dietary restriction in long-lived dwarf flies.

Aging Relevance Analysis/Source:

GenAge