Dominant-negative S6k

Species: Fruit fly (Taxid: 7227)
Factor: S6k
Manipulation: Loss-of-Function, Overexpression, Mutation
Effect:

Ubiquitous overexpression of a dominant-negative form of S6k (alias dS6K) increases mean lifespan by 22%. Overexpression of a dominant-negative form of S6k protects mutants from deleterious effects of rich food, as if mimicking the effect of DR [15186745].

Mean: +22

References:
  • 15186745: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • da-GAL4/UAS-dS6kKQ vs. +/da-GAL4 : 15.4(mean) 29.0(max) <0.0001(p-value)
  • DJ634-GAL4/UAS-dS6kKQ vs. +/DJ634-GAL4 : 24(mean) 29.0(max) <0.0001(p-value)



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