Dominant negative Tor

Species: Fruit fly (Taxid: 7227)
Factor: Tor
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Expression of a dominant-negative form of Tor extends lifespan [15186745]. Ubiquitious overexpression of dTOR with the da-GAL4 driver of UAS-dTOR(FRB) which contains the 11kDA FKB12-rapamycin binding domain led to a mean and maximum lifespan increase of 15% (24%) and 29% at 29°C and of 50% (26%) and 13% at 25°C, respectively [15186745].

Overexpression of the dominant-negative form of Tor specifically in the fat and muscle tissues is sufficient to extend the mean and maximum lifespan by 24 and 19%, respectively [15186745].

Overexpression of UAS-dTOR(WT) or UAS-dTOR(TED) prevents eclosion to adulthood [15186745].

Mean: +15 to +50
Median: +13 to +29

References:
  • 15186745: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • da-GAL4/UAS-dTORFRB vs. +/da-GAL4 : 15.4(mean) 29.0(max) <0.0001(p-value)
  • da-GAL4/UAS-dTORFRB vs. +/da-GAL4 : 50(mean) 12.7(max) <0.0001(p-value)
  • DJ634-GAL4/UAS-dTORFRB vs. +/DJ634-GAL4 : 24(mean) 19.4(max) <0.0001(p-value)



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