Thor mutation

Species: Fruit fly (Taxid: 7227)
Factor: Thor
Manipulation: Loss-of-Function, Mutation
Effect:

Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males). foxo (alias dFOXO) and Thor null mutants are compromised in stress resistant. Stress resistance of foxo null mutants is rescued by Thor overexpression [16055649]. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Thor null mutants have a wild-type similar reduction in egg production upon DR [19804760].

Median: -25

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



  • Edit / Update (Admin) | Delete

    Comment on This Data Unit