Denigma: Intervention

Ilp2/Ilp3/Ilp5 mutation

Species: Fruit fly (Taxid: 7227)
Factor: Ilp3 Ilp5 Ilp2
Manipulation: Loss-of-Function, Mutation, Deletion
Effect:

Ilp5 null mutants have a normal lifespan under AL and a normal DR response. Ilp2 Ilp3 Ilp5 triple null mutants fail to have a normal response to DR. Their response is right shifted, with mutants being shorter-lived compared to wild-type on low but longer-lived on high yeast concentrations [20195512].

References:

20195512: Molecular evolution and functional characterization of Drosophila insulin-like peptides.

Aging Relevance Analysis/Source:

GenAge