Denigma

30% Dietary restriction

Species: House mouse (Taxid: 10090)
Factor:
Manipulation: Dietary Restriction, Diet Intervention
Effect:

30% dietary restriction starting at 2 months of age increases overall, average, median and maximal lifespan. Knockout of Ghr failed to respond with lifespan extension to this regimen [16682650].


References:
  • 16682650: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.


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