Denigma

Gh antagonist overexpression

Species: House mouse (Taxid: 10090)
Factor: Gh
Manipulation: Loss-of-Function, Overexpression, Mutation
Effect:

Overexpression of a growth hormone antagonist (a mutated bovine growth hormone that competes with the endogenous one) has no effect on lifespan [12933651].


References:
  • 12933651: Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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