Vitamin C treatment

Species: Nematode (Taxid: 6239)
Factor: Vitamin C
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].

Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628].


References:
  • 21151885: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
  • 23075628: Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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