Denigma: Intervention

drr-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: drr-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi of drr-1 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. drr-1 RNAi significantly extends mean lifespan of wild-type by 37 - 44%, of daf-16 mutants by 18%, and of daf-2 mutants by 14%, but does not extend significantly the lifespan of eat-2 mutants. drr-1 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as causes a slender appearance. drr-1 mRNA is 2-fold downregulated in response to DR [16103914].

Mean: +3 to +44
Median: +8

References:

16103914: New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.

15998808: A systematic RNAi screen for longevity genes in C. elegans.

Aging Relevance Analysis/Source:

GenAge