Denigma

ARO7 deletion

Species: Budding yeast (Taxid: 4932)
Factor: ARO7
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Under starvation/extreme DR deletion of ARO7 increases mean chronological lifespan and confers higher resistance to heat-shock, but made cell more sensitive to acetic acid and leads to growth defects. In W303-1A background ARO7 deletion causes an even more severe growth defect and mutants are short-lived [20657825].


References:
  • 20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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