Denigma

ACB1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: ACB1
Manipulation: Loss-of-Function, Knockout, Deletion
Effect:

ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825].


References:
  • 20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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