Denigma

Adcy5 knockout

Species: House mouse (Taxid: 10090)
Factor: Adcy5
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Adcy5 knockout mice are to cardiac stress and have an increased median lifespan of 30% as well as an increased maximal lifespan of 12%. Further, they are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function [17662940].

Median: +30
Maximum: +12

References:
  • 17662940: Type 5 adenylyl cyclase disruption increases longevity and protects against stress.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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