Denigma: Intervention

HNRNPD deletion

Species: House mouse (Taxid: 10090)
Factor: HNRNPD
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

HNRNPD deletion leads to accelerated aging as evidenced by strinking telomere erosion, markedly increased DNA damage repsosne at telomere ends, pronounced cellular senescence and rapid premature aging that increases with successive generations [Pont et al., 2012].

Aging Relevance Analysis/Source:

GenAge