Denigma

HES1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HES1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of HES1 (alias OSH5) extends mean replicative lifespan by 27% and is non-addative with moderate DR. Deletion of OSH5 delays different steps of endocytosis, a sterol-requireing process. [Xia et al., unpublished].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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