old-1 overexpression

Species: Nematode (Taxid: 6239)
Factor: old-1
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of old-1 in transgenic animals increases mean and maximum lifespan by 40-100% (average 65%) and 97%, respectively. old-1 overexpression of increases stress resistance (to heat by 20% and ultraviolet irradiation by 33%) without altering development or fertility. Effects of old-1 on lifespan and stress resistance is under regulation of daf-16 [9768365].

Mean: +40 to +100
Maximum: +97

References:
  • 9768365: Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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