Denigma

sams-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: sams-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [16103914]. sams-1 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616].

Mean: +14 to +15

References:
  • 18331616: Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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