SNCA overexpression

Species: Nematode (Taxid: 6239)
Factor: SNCA
Manipulation: Gain-of-Function, Overexpression, Mutation
Effect:

Transgenic lines overexpressing either human wild-type or mutant (A53T) forms of the SNCA (alpha-synclein) gene under a pan-neuronal promoter live on average about 25% longer, even in weak (m577) and strong (e1370) daf-2 mutant backgrounds, and exhibited decreased pharyngeal pumping and egg-laying. Wild-type SNCA crossed into eat-2(ad1113) does not significantly effect lifespan compared to that of the background strain. Pumping rate in wild-type SCNA and A53T SCNA overexpression mutants were less than control already at day 1 of adulthood. The attenuation of lifespan exptesion by SNCA overexpression by growing on thick bacterial lawns, suggests that DR may explain some fo the effects on lifespan. SCNA overexpression increases average lifespan by 21.3% (wild-type) and 16.3% (A53T) [16782295].

Mean: +26 to +34
Maximum: +19 to +31

References:

16782295: Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.

Aging Relevance Analysis/Source:

GenAge

GenDR

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