K5-Tert overxpression

Species: House mouse (Taxid: 10090)
Factor: Tert
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of telomerase results in a high cancer incidence but also a modest mean (10%) and maximum lifespan extension accompanied by a lower incidence of some age-related degenerative diseases, in particular those related to kidney function and germline integrity [15688016].

Mean: +10

References:
  • 15688016: Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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