Denigma

bar-1 mutation

Species: Nematode (Taxid: 6239)
Factor: bar-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404].

Mean: -44
Maximum: -18

References:
  • 15905404: Functional interaction between beta-catenin and FOXO in oxidative stress signaling.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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