Denigma

sir-2.1 deletion

Species: Nematode (Taxid: 6239)
Factor: sir-2.1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

sir-2.1 deletion slightly reduces lifespan of wild-type [16860373]. sir-2.1 suppresses longevity of unc-13 and eat-2, but not daf-2 or unc-64 mutants [16860373]. sir-2.1 is therefore partially required for lifespan extension from mutation of eat-2 [16860373], but is completely independent for lifespan extension from DR using a reduced feeding protocol [Kaeberlein et al. in press]. sDR increases lifespan of wild-type and sir-2.1 mutants to the same extent [19239417].


References:
  • 16860373: C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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