Rapamycin treatment

Species: Nematode (Taxid: 6239)
Factor: Rapa
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment with rapamcyin increases mean, median, 75th %ile and maximum lifespan by 19-29, 17-29, 24-32 an 19%, respectively on OP50. On HT115 rapamycyin extends mean, median and 75th %ile of lifespan by 8-36, 4-46 and 12-44%, respectively. Rapamycin robustly increases lifespan in two daf-16 mutants (mgDf47 and mu86) with or without FUdR and with growth on either the standard strain OP50 or the feeding RNAi strain HT115 [22560223].

Mean: +8 to +29
Median: +4 to +46
Maximum: +19

References:
  • 22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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