raga-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: raga-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223].

Mean: +9 to +42
Median: +26 to +28
Maximum: +35

References:
  • 22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



  • Edit / Update (Admin) | Delete

    Comment on This Data Unit