daf-15 RNAi

Species: Nematode (Taxid: 6239)
Factor: daf-15
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

daf-15 RNAi only during the adulthood increases mean and 75th %ile lifespan by 7-21 and 8-20%, respectively, which was abolished by either skn-1 or daf-16 mutation (with and without FUdR). daf-15 knockdown dramatically increases stress-tolerance in an skn-1, but not daf-16-dependent manner. Autophagy (measured by LGG-1 puncta) was increased by daf-15 RNAi [22560223].

Mean: +7 to +21

References:
  • 22560223: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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