Denigma

Overexpression of constitutive nuclear SKN-1

Species: Nematode (Taxid: 6239)
Factor: skn-1
Manipulation: Gain-of-Function, Overexpression, Mutation
Effect:

skn-1 transgenes that overexpress a constitutive nuclear form of SKN-1 in the intestine extend the mean lifespan by 5-21%, independently of DAF-16 [18358814].

Mean: +5 to +21

References:
  • 18358814: Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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