Rapamycin treatment

Species: House mouse (Taxid: 10090)
Factor: Rapa
Manipulation: Drug treatment
Effect:

Rapamcyin increases mouse lifespan and healthspan even when administrated late in life (20 months) [19587680].

Rapamycin enhances learning and memory in young mice and improves these faculties in old mice thereby negating the normal decline in these functions with age. Rapamycin boost levels of neurotransmitters associated with neural plasticity. Rapamycin also lowered anxiety and depressive-like behaviour at all ages from 4, 12 and 28 months. "Happy, feel-good" neurotransmitters such as serotonin, dopamine and norepinephrine are all significantly augmented in the midbrains of rapamycin treated mice [http://denigma.de/url/37].

Treatment with rapamycin increased lifespan and suppresses spontanous tumorgenesis in inbred female mice [22107964].


References:
  • 19587680: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
  • 22107964: Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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