super-Trp53

Species: House mouse (Taxid: 10090)
Factor: Trp53
Manipulation: Gain-of-Function, Overexpression
Effect:

super-p53 mice generate by integrating a transgenic copy of a large genomic segment containing an intact and complete copy of p53 have an ehanced response to DNA damage, are significantly protected from cancer and had no indication of accelerated aging [12426394].


References:
  • 12426394: "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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