Denigma: Intervention

daf-1 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085].

Mean: +18 to +46
Maximum: +29

References:

17900898: The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.

11242085: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge