daf-3 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-3
Manipulation: Loss-of-Function, Mutation
Effect:

daf-3(mgDf90) mutation decreases mean lifespan by 0-16% and maximum lifespan by up to 9-21%. daf-3(mgDf90) decreases mean lifespan even by 19% [17900898]. Mutation of daf-3 results in a wild-type lifespan, but greatly extends the lifespan of the long-lived daf-9 mutant [11782415]. daf-3 mutations are dauer defective.

Mean: 0 to -19
Maximum: -9 to -21

References:
  • 17900898: The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.
  • 11782415: DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



  • Edit / Update (Admin) | Delete

    Comment on This Data Unit