SOD2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: SOD2
Manipulation: Loss-of-Function, Knockdown, Mutation, Deletion
Effect:

SOD2 deletion decreases replicative lifespan by 72% [17460215]. SOD2 deletion decreases chronological lifespan [21076178]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [12586694].

SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [10222047].

Mean: -72

References:
  • 21076178: Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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