spe-26 mutation

Species: Nematode (Taxid: 6239)
Factor: spe-26
Manipulation: Loss-of-Function, Mutation
Effect:

spe-26 mutation in both hermaphrodites and mated males renders them defective in spermatogenesis and increases mean lifespan by about 65%. In hermaprodites spe-26(hc138ts) mutation increases mean and maximum lifespan by 46 and 29%, respectively. Mating does not reduce lifespan in male with spe-26 mutation. Animals with a different spe-26 allele, it118ts, have a similar increase in mean lifespan both in mated males and mated hermaphrodites. Mating even increases spe-26 mutant male lifespan, although the increase is slight (16% increase in mean and 13% increase in maximum lifspan. While compared to wild-type mated spe-26 males have an increase in mean and maximum lifespan of 81 and 63%, respectively, in comparison to wild-type [1448167]. spe-26 loss of function mutation extends lifespan [8807294].

Mean: +46 to +81
Maximum: +29 to +63

References:
  • 1448167: Production of sperm reduces nematode lifespan.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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