daf-7 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-7
Manipulation: Loss-of-Function, Mutation
Effect:

daf-7 mutation does not significantly change lifespan [8247153]. Mutations in daf-7 cause up to 50% mean and maximum life-extension. This effect is dependent upon daf-3 and on daf-16 but independent of daf-2. daf-7(e1372) increases mean and maximum lifespan by 13-39% and 55%, respectively. daf-7(m62) increases mean and maximum lifespan by 20-29% and 29% [17900898].

Mean: +13 to +39
Maximum: +29 to +55

References:
  • 17900898: The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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