Denigma

mrpl-47 RNAi

Species: Nematode (Taxid: 6239)
Factor: mrpl-47
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi against mrpl-47 extends mean and maximum lifespan by 18% and 50%, respectively [12447374]. This lifespan extension is not suppressed by daf-16 mutation (mgDF74). mrpl-47 knockdown results in lower ATP content and oxygen consumption [12447374].

Mean: +18
Maximum: +50

References:
  • 12447374: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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