W09C5.8 RNAi

Species: Nematode (Taxid: 6239)
Factor: W09C5.8
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434].

W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374].

Mean: +62
Maximum: +50

References:
  • 12447374: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
  • 19074434: Complex I function is defective in complex IV-deficient Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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