Denigma

F57B10.3 RNAi

Species: Nematode (Taxid: 6239)
Factor: F57B10.3
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374].

Mean: +21
Maximum: +48

References:
  • 12447374: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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