F28B3.5 RNAi

Species: Nematode (Taxid: 6239)
Factor: F28B3.5
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference of F28B3.5 extends mean lifespan by 31% and 55%, respectively, and does not cause any developmental pleiotropies nor defects in mitochondrial morphology. Lifespan extension by F28B3.5 is suppressed by daf-16. F28B3.5 animals have lower ATP content and oxygen consumption [12447374].

Mean: +31
Maximum: +55

References:
  • 12447374: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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