Denigma: Intervention

clk-1 mutation

Species: Nematode (Taxid: 6239)
Factor: clk-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutations in clk-1 slow down development and extend lifespan by 30%. Mutation of both clk-1 and daf-2 results in nearly 5-fold (500%) increase in lifespan [8638122]. Food restriction by eat-2 mutation does not further extend the long lifespan of clk-1 mutant [9789046]. DR and clk-1 mutations may extend lifespan by a similar process. DR by intermittent fasting (IF) significantly extends lifespan of clk-1 mutants, but to a lesser extent than that of wild-type [19079239]. clk-1 mutants do not respond to sDR-induced lifespan extension [19239417].

clk-1 encodes a enzyme participating in coenzyme Q synthesis [9020081; 11136229]. clk-1 mutants have a decreased pharyngeal pumping and may provoke volunteering DR [9789046]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthing of embryonic development, post-embryonic development, and adult rhythmic behaviours such as defecation, swimming and pharyngeal pumping [7768437]. clk-1 mutant requires coeznyme Q [11136229].

Mean: +30

References:

8638122: Determination of life-span in Caenorhabditis elegans by four clock genes.

19079239: Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.

19239417: Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.

9020081: Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

11136229: A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.

9789046: The genetics of caloric restriction in Caenorhabditis elegans.

7768437: Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

Aging Relevance Analysis/Source:

GenAge