Denigma

age-1 mutation

Species: Nematode (Taxid: 6239)
Factor: age-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740].

age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142].

Mean: +99
Maximum: +117

References:
  • 18828672: Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit