Denigma

daf-16 RNAi

Species: Nematode (Taxid: 6239)
Factor: daf-16
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. RNAi against daf-16 decreases lifespan of wild-type, daf-2 or glp-1 mutants [22509016; 16530050]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. daf-16 RNAi decreases mean lifespan by 27% [18828672].

Mean: -27 to 50
Maximum: -54

References:
  • 22509016: Midlife gene expressions identify modulators of aging through dietary interventions.
  • 18828672: Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • daf-16 RNAi vs. control : -20.3(mean) <0.0001(p-value)
  • daf-16 RNAi vs. control : -15.8(mean) <0.0001(p-value)
  • wild-type RNAi vs. wild-type ( 20°C ) : -27.8(mean) -17.4(max)
  • wild-type RNAi vs. wild-type ( 20°C ) : -30(mean) -20.8(max)

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