Denigma

pex1 mutation

Species: Fruit fly (Taxid: 7227)
Factor: pex1
Manipulation: Gain-of-Function, Loss-of-Function
Effect:

Mutation of the promoter region of pex1(S4868), results in lower expression levels and increases lifespan in males and females by 16% and 13%, respectively. pex1 mutation increases mean and maximum lifespan and males/females by 27-23/14-19% and 0-15%, respectively [22509016].

Mean: +14 to +27
Maximum: 0 to +15

References:
  • 22509016: Midlife gene expressions identify modulators of aging through dietary interventions.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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