cco-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: cco-1
Manipulation: Loss-of-Function, Knockout, RNA Interference
Effect:

RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223].

Mean: +22 to +73
Maximum: +50 to +90

References:
  • 19954334: Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice.
  • 11707916: Longevity and aging: beneficial effects of exposure to mild stress.
  • 10219000: Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.
  • 22484922: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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