RNA interference of cyc-1 results in a 45-87% increase in mean lifespan [16103914]. cyc-1 RNAi extends mean and maximum lifespan by 66 and 79%, respectively. RNAi of cyc-1 during larval stages is necessary and sufficient for lifespan extension, while RNAi of cyc-1 only during the adulthood fails to extend lifespan [12471266]. RNAi against cyc-1 increases mean and 75th %ile lifespan by 8-28 and 16-29%, respectively [22560223]. cyc-1 RNAi results in reduced pharyngeal pumping, defection, motility, ATP levels (by 60-80%), an body size. Mutation of daf-16 fails to prevent lifespan extenison by RNAi of cyc-1 and mutation of daf-2 further extends the lifespan of cyc-1 RNAi animals [12471266].
Mean: +8 to +87
GenAge
GenDR
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