RNA interference of nuo-2 extends lifespan [15998808]. RNAi against nuo-2 increases mean and maximum lifespan by 33 and 70%. RNAi of nuo-2 during larval stages is necessary and sufficient for increased lifespan, while RNAi only during adulthood fails to extend lifespan. daf-16 mutation fails to prevent lfiespan extension confered by nuo-2 RNAi, while mutation of daf-2 further extend the lifespan of nueo-2 RNAi animals [12471266].
nuo-2 RNAi causes reduced rate of growth to adulthood, reduced pharyngeal pumping, reduced body size, reduced ATP levels (by 60-80%), and reduced defecation and motility [12471266].
Mean: +33
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