mrps-5 RNAi

Species: Nematode (Taxid: 6239)
Factor: mrps-5
Manipulation: Loss-of-Function, Knockdown, RNA Interference

Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443].

Mean: +60

  • 23698443: Mitonuclear protein imbalance as a conserved longevity mechanism.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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