Zw overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Zw
Manipulation: Gain-of-Function, Overexpression

Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased [18809674].

G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased [18809674].

Mean: +16 to + 38

  • 18809674: Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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