pex16 mutation

Species: Fruit fly (Taxid: 7227)
Factor: pex16
Manipulation: Loss-of-Function, Mutation

pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons [21826223].

Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system [21826223].

Mean: -33 to -75

  • 21826223: Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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